SWAN Repository resources have transferred to the new NIA Central Biorepository. Applications for obtaining specimens and data will no longer be accepted here, but more information can be found at https://agingresearchbiobank.nia.nih.gov

Welcome to the SWAN Repository

The SWAN Study

The Study of Womens Health Across the Nation (SWAN) is an active multi-site, multi-disciplinary, longitudinal study of women’s health. Initially funded in 1994 by the NIA, NINR, and ORWH, the overall goal of SWAN is to describe the biological, behavioral, and psychosocial characteristics that occur during midlife and the menopausal transition. SWAN focuses on the impact of menopause on age-related chronic diseases, such as diabetes, cardiovascular disease, depression, bone loss and osteoporosis, as well as physical and cognitive functioning.

For more information, visit the SWAN Study website.

The SWAN Population

SWAN has seven clinical study sites located in six states, two in California, and one each in Chicago, Boston, Detroit area, northern New Jersey and Pittsburgh. The SWAN cohort was recruited from these areas and enrolled in 1996-97 and consists of 3,302 African American, Caucasian, Chinese American, Hispanic and Japanese American women. Cohort members were pre-menopausal, not taking hormones and between 42–52 years of age at the time of enrollment. SWAN participants are seen annually or bi-annually for clinic visits, which include interviews, measurements, and the collection of blood and urine samples. SWAN participants have now been seen for the baseline and 13 follow-up visits.

See the SWAN Study timeline.

Read more about the SWAN study designs and measures (PDF).

The SWAN Repository — Resources available to you

The SWAN Repository is the biospecimen bank of the SWAN study. All stored specimens are from the 3,302 SWAN participants. There are currently nearly 1.8 million samples, collected across the 14 clinic visits. Both SWAN Specimens and Data are available to the scientific community.

  • Available Biospecimens include Serum, Plasma, and Urine from annual follow-up visits, as well as DNA and Immortilized Cell Lines on approximately 1500 SWAN participants. Also, a subset of 800 women have provided daily urine samples during one menstrual cycle each year until reaching menopause. This collection is known as the Daily Hormone Study (DHS).
  • SWAN Data *: Nearly 20,000 variables have been collected over the life of the SWAN study, and have been organized in a searchable directory in our Data Warehouse *. Registered users are able to search variables, assemble lists, and save personal libraries.

NOTE: Users cannot directly access SWAN data.

Public Use Datafiles

Investigators interested in using Core SWAN data only (and no biospecimens) should request a public use dataset from ICPSR or direct their request to the SWAN Coordinating Center. Only those investigators interested in using genetic data or biospecimens should submit a request through the Repository.

Requesting Data & Specimens

Applying for SWAN Repository resources can now be done online, using these forms:

  • STEP 1: Complete the Initial Inquiry/Checklist *.
    • This brief initial assessment allows Repository staff to confirm availability of requested materials and provide a sample size estimate to applicants.
    • Click here for a preview of the Inquiry Checklist form.
  • STEP 2: Complete the full Application.
    • Investigators are encouraged to have Applications submitted, fully completed and with all questions answered, at least 6 weeks prior to grant deadline.
    • Similar to NIH applications, this form includes the major sections: Introduction, Specific Aims and Hypotheses; Background & Significance; Preliminary Studies; and Methods & Materials.
    • There must be assurances that a SWAN investigator will join the approved investigation to facilitate the appropriate and effective utilization of the information resources provided to the grantee and to provide assistance to the investigators toward the successful completion of the project. This Repository project investigator is expected to have full status accorded a co-investigator on any research endeavor.

      If the lead investigator of a Repository application is not a SWAN investigator, a SWAN investigator knowledgeable in the area of the proposed work must be included in the study. This person will be known as the SWAN Sponsor.
    • The submitted Application will be reviewed by:
    • Click here for a preview of the Application form.
  • See the full schematic of Repository application and review processes
  • See the current list of Completed and Approved Repository Projects
  • Materials for approved applications
    • Required forms and Agreements for investigators with approved Repository applications are also available online

* Registration required. Click here to register with your name, email and a password.