SWAN Repository Administration and Committees

The SWAN Repository is administered and managed at the University of Michigan, by:
  • Dr. Sioban Harlow, PI
  • Dr. Daniel McConnell, Co-I
  • Steffenie Merillat, Repository Manager
  • Robin Wylie, Web Developer
  • Charlotte Carlson, Administration

The SWAN Repository Organization (SRO)

Purpose

The SRO is responsible for three major activities: Repository application reviews, Repository operations monitoring, and Repository policies and procedures.

Repository Application review includes: reviewing proposals for sample size and adequate power; negotiating reasonable sample requests with respect to number and volume of samples to ensure lowest necessary impact on inventory, especially to scarce samples; ensuring acceptable lab procedures; and performing New Studies functions (check for overlap). The reviews are performed online, through a question-centered website where retrieval and review of submitted documents, commenting, and voting are securely completed.

Repository operations monitoring includes reviewing quarterly reports from the physical biobank, SeraCare Life Services. The SRO also participates in the oversight and direction of activities such as inventory investigations, molecular work, aliquoting, and culling.

SRO members are asked to provide input and expertise to help shape Repository policies and procedures. This may include such things as cost-recovery programs, data-sharing policies, sample value assignments, and promotional programs to increase utilization of Repository resources.

Members
  • Sioban Harlow, PhD, University of Michigan, SWAN Repository Principal Investigator
  • Daniel McConnell, PhD, University of Michigan, SWAN Repository Co-Investigator
  • Sherri-Ann Burnett-Bowie, MD, MPH, Massachusetts General Hospital, SWAN New Studies Chair
  • Sybil Crawford, PhD, University of Massachusetts, SWAN Coordinating Center Statistician
  • Elaine Gunter, PhD, Repositorian, Owner/consultant at Specimen Solutions LLC
  • Sharon Kardia, PhD, University of Michigan, Statistical Geneticist
  • Bill Lasley, PhD, University of California at Davis, Co-Investigator
  • Steffenie Merillat, BS, SWAN Repository Manager (ex-officio)
  • Winnie Rossi, MA, NIH/NIA, NIA Project Officer
  • Janet Sinsheimer, PhD, UCLA, Statistical Geneticist

Swan Repository Advisory Group (SRAG)

Purpose

The SWAN Repository is in a unique position to expand research opportunities in the health of women at the mid-life. To assist in making optimal use of the Repository resources, a special Advisory Group was organized. This Advisory Group includes: representative SWAN investigators; scientists outside of SWAN with expertise in epidemiology, genetics, geriatrics, and ethics; and Ad Hoc scientists for review of applications with subject areas outside the expertise of current SRAG members.

SRAG members are responsible for reviewing the quality of the science in SWAN Repository applications requesting genetics specimens or any specimens deemed rare or "reserved". Each vial in the Repository has been evaluated for scientific value and scarcity, and some have been flagged as reserved. SRAG members provide ethical consideration of the use of these biological materials, and also provide guidance in developing DNA resources.

Applications are assigned to reviewers most closely matching the scientific area of the proposal. Reviews are completed and submitted online through a set of objective questions with opportunities for comments and overall summaries. If necessary, SRAG conference calls are held to discuss applications or potential impact on inventory resources.

Members
  • Sioban Harlow, PhD, University of Michigan, SWAN Repository Principal Investigator (ex-officio)
  • Daniel McConnell, PhD, University of Michigan, SWAN Repository Co-Investigator (ex-officio)
  • Ann Boyd, PhD, Hood College, Ethicist
  • Gail Greendale, MD, UCLA, SWAN Site Principal Investigator, SWAN Representative
  • Sharon Kardia, PhD, University of Michigan, Statistical Geneticist
  • Howard Kravitz, DO, MPH, Chicago (Rush) Site Principal Investigator, SWAN Representative
  • Nancy Nadon, PhD, NIH/NIA, NIA Representative (new Rep to be named)
  • Janet Sinsheimer, PhD, UCLA, Statistical Geneticist
  • Jeff Williamson, MD, Wake Forest, Geriatrician